Edward was born about 1700 in Maryland, the son of Richard Clagett and Deborah Dorsey.
He has died but the date and place are unknown.
His wife was Eleanor Bowie, who he married in 1732 in Maryland. Their six known children were Richard (c1735-?), Mary (c1735-?), John (1733-?), Nicholas (1745-?), Wiseman (1748-?) and Eleanor Bowie (1749-?).